WitrynaSince the discovery that isotype switching is mediated by a somatic rearrangement event, progress in the field of isotype switching has come a long way: switch factor activity for several T-cell-derived cytokines has been discovered. ... Immunoglobulin Switch Region T-Lymphocytes / immunology* Transforming Growth Factor beta / … Witryna18 cze 1993 · Recombination to a particular switch region was abolished in mice that were altered to lack sequences that are 5' to the s gamma 1 region, which directly implicates the functional importance of 5' switch region flanking sequences in the control of class switch recombination. Expand

Increased targeting of donor switch region and IgE in Sgamma1

WitrynaBinding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination Witryna1 gru 2014 · Here, we vary the G-density of different portions of the switch region in a murine B cell line. We find that both class switch recombination (CSR) and R-loop … nottinghasmhire formulary

IGH immunoglobulin heavy locus [ Homo sapiens (human) ]

Witryna21 gru 2006 · Introduction. Class switch recombination (CSR) is a reaction that alters antibody effector functions by replacing the immunoglobulin constant regions 1.This … Witryna1 sty 1995 · Central to the regulation and mechanism of class switch recombination is the understanding of the relationship between transcription and DNA recombination. We demonstrated previously, using minichromosome substrates, that physiologically oriented transcription Is required for recombination to occur between switch regions. In this … WitrynaSomatic hypermutation (SHM) and class switch recombination (CSR) cause distinct genetic alterations at different regions of immunoglobulin genes in B lymphocytes: point mutations in variable regions and large deletions in S regions, respectively. Yet both depend on activation-induced deaminase (AID), the function of which in the two … nottinghamshire youth offending team